Synthesis of meta-(Indol-3-yl)phenols from Indoles and Cyclohexenone via Palladium(II)-Catalyzed Oxidative Heck Reaction and Dehydrogenative Aromatization in a One-Step Sequence

Son, Seung Hwan; Shin, Jeong-Won; Won, Hyuck-Jae; Yoo, Hyung-Seok; Cho, Yang Yil; Kim, Soo Lim; Jang, Yoon Hu; Park, Boyoung Y.; Kim, Nam-Jung

doi:10.1021/acs.orglett.1c02679

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Synthesis of meta-(Indol-3-yl)phenols from Indoles and Cyclohexenone via Palladium(II)-Catalyzed Oxidative Heck Reaction and Dehydrogenative Aromatization in a One-Step Sequence

Son, Seung Hwan;
Shin, Jeong-Won;
Won, Hyuck-Jae;
Yoo, Hyung-Seok;
Cho, Yang Yil;
외 4명

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8

초록

Facile construction of a meta-(indol-3-yl)phenol framework with a wide substrate scope (a total of 25 compounds) via a palladium(II)-catalyzed oxidative Heck reaction and dehydrogenative aromatization in a one-step sequence is reported. This methodology affords a novel route for the privileged structures that are challenging to access via a direct link between indole and phenol, in a highly efficient and atom-economical manner.

키워드

REGIOSELECTIVE SYNTHESIS; AEROBIC DEHYDROGENATION; C-H; ARYLATION; CYCLOHEXANONES; 3-ARYLINDOLES; ALKENYLATION; SYSTEM

제목: Synthesis of meta-(Indol-3-yl)phenols from Indoles and Cyclohexenone via Palladium(II)-Catalyzed Oxidative Heck Reaction and Dehydrogenative Aromatization in a One-Step Sequence

저자: Son, Seung Hwan; Shin, Jeong-Won; Won, Hyuck-Jae; Yoo, Hyung-Seok; Cho, Yang Yil; Kim, Soo Lim; Jang, Yoon Hu; Park, Boyoung Y.; Kim, Nam-Jung

DOI: 10.1021/acs.orglett.1c02679

발행일: 2021-10-01

유형: Article

저널명: Organic Letters

권: 23

호: 19

페이지: 7467 ~ 7471

언어: ENG

출판사: AMER CHEMICAL SOC

발행국가: 미국

분량: 5 페이지

ISSN: E 1523-7052
P 1523-7060