β-Cyclodextrin hydrogel incorporating hydrophobically modified poly(N-isopropylacrylamide) for a temperature-dependent release

초록

Hydrogels exhibiting a temperature-dependent release were prepared by incorporating hydrophobically modified poly(N-isopropylacrylamide) (HmPNIPAM) into beta-cyclodextrin hydrogels (beta-CD hydrogels). The specific loading of HmPNIPAM was about 0.0069g HmPNIPAM/g beta-CD hydrogels. The incorporation of the polymer was qualitatively conformed by FT-IR spectroscopy and SEM. The percent release of blue dextran in 24 hr at 20 degrees C (about 77%) was markedly higher than those obtained at 35 degrees C and 45 degrees C (about 53 and 55%, respectively). At the higher temperatures, the volume of the hydrogel could decrease upon the thermal contraction of HmPNIPAM, leading to a smaller mesh and a suppressed release. In fact, the swelling ratio in 24 hr at 35 degrees C and 45 degrees C (about 396% and 405%, respectively) was obviously lower than that obtained at 20 degrees C (about 465%). Copyright (C) 2011 John Wiley & Sons, Ltd.

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