Improved charge-transfer enhancement by codoping Mg/Zn into ZrO2 for quinolone antibiotic drug determination

초록

Noble metal-based surface-enhanced Raman scattering (SERS)-active substrates have been developed for decades. However, nonreproducible aggregation and photoinduced molecular degradation limit the development of SERS technology. To overcome the shortcomings of noble metal-based SERS substrates, we designed ZrO2-based nanoparticles (NPs). By doping Mg and/or Zn ions into these ZrO2 NPs, the SERS activity was significantly improved. Mg/Zn codoping of ZrO2 resulted in a much higher oxygen deficiency, thereby providing a sufficient surface state energy (Ess) level to enable charge transfer (CT). The primary contribution for the Mg/ Zn-codoped ZrO2 was determined to be from the CT resonance effect, resulting in an enhancement factor (EF) as high as 104. Most importantly, the CT-induced enhancement of Raman scattering based on Mg/Zn-codoped ZrO2 has already demonstrated some promising applications in highly sensitive quinolone antibiotic drug determination. Different kinds of quinolone antibiotic drugs can be easily identified and quantitatively analyzed with high sensitivity and reproducibility.

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