트레드밀 운동이 전립샘비대 유도 쥐의 염증성 사이토카인 발현 및 전립샘 조직의 항산화효소 활성에 미치는 영향

초록

This study was to investigate the effects of treadmill exercise on inflammatory cytokines expression and antioxidant enzymes activity in prostate tissue of BPH-Induced rat. At 6 weeks of age, male S.D rats(N=36) were randomly assigned to : sham operation group(SO, n=12), BPH group(BPH, n=12), BPH+treadmill exercise group(BPH+TE, n=12). Rats in the exercise group run on a treadmill at a speed of 12-25m/min for daily (30-40 min/day) for 12 weeks. After 12 weeks treadmill exercise, serum IL-1β and TNF-α levels were significantly decreased in exercise groups compared with BPH group(p<.01). IL-6 and COX-2 mRNA expression in Prostate Tissue were significantly decreased in exercise groups compared with BPH group(p<.01). In the Prostate Tissue, SOD and GPx activities were significantly increased in exercise groups compared with BPH group(p<.01). In conclusion, the results of this study indicate that treadmill exercise improved BPH status by activation of antioxident enzymes and reduce of inflammatory cytokines in prostate tissue of BPH-Induced rat.

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