A small-molecule antagonist of the hedgehog signaling pathway

Lee, Jongkook; Wu, Xu; di Magliano, Marina Pasca; Peters, Eric C.; Wang, Yan; Hong, Jiyong; Hebrok, Metthias; Din, Sheng; Cho, Charles Y.; Schultz, Peter G.

doi:10.1002/cbic.200700403

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A small-molecule antagonist of the hedgehog signaling pathway

Lee, Jongkook;
Wu, Xu;
di Magliano, Marina Pasca;
Peters, Eric C.;
Wang, Yan;
외 5명

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69

초록

Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK1 84 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.

키워드

RETINOIC ACID SYNTHESIS; ALCOHOL-DEHYDROGENASE; SONIC HEDGEHOG; IDENTIFICATION; INHIBITION; CYCLOPAMINE; BINDING

제목: A small-molecule antagonist of the hedgehog signaling pathway

저자: Lee, Jongkook; Wu, Xu; di Magliano, Marina Pasca; Peters, Eric C.; Wang, Yan; Hong, Jiyong; Hebrok, Metthias; Din, Sheng; Cho, Charles Y.; Schultz, Peter G.

DOI: 10.1002/cbic.200700403

발행일: 2007-11-05

유형: Article

저널명: ChemBioChem

권: 8

호: 16

페이지: 1916 ~ +