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초록

Reactive oxygen species serve as critical mediators in the induction of cancer cell death, with hydrogen peroxide (H2O2) in particular functioning as a pivotal trigger for antitumor responses due to its inherent stability and diffusibility within biological systems. H2O2 can be harnessed in conjunction with diverse therapeutic mechanisms, including Fenton reactions, modulation of local pH, and controlled drug release. Glucose oxidase (GOx or GOD), by utilizing the abundant glucose present in the tumor microenvironment, continuously generates H2O2 while simultaneously inducing localized acidification and oxidative stress. Owing to these properties, GOx-based therapies have emerged as promising next-generation anticancer platforms, capable of disrupting redox homeostasis, overcoming drug resistance, and inducing immunogenic cell death through multiple pathways. Accordingly, the rational design of efficient delivery systems and the development of combinatorial therapeutic strategies are considered central directions in GOx-based cancer therapy research. In this review, we aim to provide a comprehensive perspective on the mechanisms of H2O2-mediated oxidative stress induced by GOx, the development of integrated therapeutic platforms, and the potential of GOx-based systems as next-generation strategies for cancer treatment.

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