Protective Effects of Supercritical Fluid Extracts of Ulmus daviana var. japonica on LPS-induced Immune Responses

초록

The objective of the present study was to investigatethe immunomodulating property of supercritical fluidextracts of Ulmus daviana var. japonica (USCF) using variousin tests. USCF has been widely used as traditional medicinedue to its pharmacological activities. In this study, weshowed that USCF possessed immunomodulating activities ascytokine production from lipopolysaccharide (LPS)-inducedimmune response model in U937 cells. The immunostimulatingeffects of USCF were further evaluated through variousimmunological tests. USCF showed excellent activity ofreducing LPS-induced immune responses from U937 cellssuch as nitric oxide and IL-1β in a dose dependent manner. UCSF (1.25 - 10 μg/ml) were gradually reduced LPS-inducednitrite production (P<0.01). Similarly, LPS-induced IL-1βrelease also significantly blocked by 10 μg/ml USCF (P<0.01). These results suggested that USCF is biologically functionalin immunomodulating properties.

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