Preparation of hydroxypropyl-β-cyclodextrin-incorporated liposomes and evaluation of their rapid release property

초록

The aim of this study was to investigate the effect of hydroxypropyl-beta-cyclodextrin (HP beta CD), widely used as a solubility enhancer, on liposomal formulations. To this end, HP beta CD was added to fabricate liposomes during the hydration process, and their physicochemical properties were evaluated. The Fourier transform infrared and nuclear magnetic resonance spectra revealed that HP beta CD could interact with the model drug, ceftazidime (CAZ), and with phosphatidylcholine, a main component of liposomes. This leads to a rapid release of CAZ depending on the concentration of HP beta CD. Nanosized HP beta CD-incorporated liposomes complied with Korsmeyer-Peppas kinetics, and the release of drug increased without significant changes in the release pattern. Our approach, which relied on supramolecule-related interactions, could provide new insights into other lipid-based formulations for accelerating drug-release properties. (C) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

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