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초록
We developed an alternative assay method without hazardous reagent of chloroform for urazamide tablets inKorean Pharmaceutical Codex. The HPLC analytical method was validated by system suitability, linearity, precision, accuracyand robustness. The linearity of the calibration curves in the desired concentration range is good (r2>0.999). Precisionwas obtained less than RSD 1.17%. Accuracy was obtained with recoveries in range of 98.12% and 99.47%. The developedassay could be expected to become valuable tools for revising the Korean Pharmaceutical Codex.
키워드
KPC; hazardous reagents; alternative methods; validation; HPLC
- 제목
- 우라자미드 정의 유해시약 대체 시험법의 개발
- 제목 (타언어)
- Development of Alternative Assay Method without Hazardous Reagent, Chloroform for Urazamide Tablets in Korean Pharmaceutical Codex
- 저자
- 이유림; 김현지; 서나래; 김경호
- 발행일
- 2014-04
- 유형
- Y
- 저널명
- 약 학 회 지
- 권
- 58
- 호
- 2
- 페이지
- 125 ~ 128