복분자 열매 추출물의 유용 생리활성 탐색

초록

The biological activities of extracts from Rubus coreanus Miq. were compared. About 70% of the growth of human hepatocarcinoma and 79% of human gastric cancer cell was inhibited in adding 1.0㎎/㎖ of the extracts of Rubus coreanus Miq. respectively. The growth of human breast cancer cells was also inhibited in adding 1.0 of the extracts as well as 78% of the human cancer cells. I쇼 was proved that the growth of human normal lung cell, scored as 15% for the extracts. Overall selectivity of the extracts on several human cancer cell line was over 5, which is higher than those from the Rubus coreanus Miq. The growth of both human immune B and T cells was enhanced up to 1.4 to 1.8 times by adding the extracts, compared to the controls. The secretion of tumor necrosis factor-alpha(TNF-α) from T cell was also increased up to 78.8pg/㎖ in adding the ethanol extract (0.5㎎/㎖ ). Ethanol extract also increased up to about 70pg/㎖ of interleukin-6(IL-6) from B cell. For screening regulate function of blood pressure, angiotensin converting enzyme(ACE) activity was inhibited up to 25% by adding the ethanol extract (1.0㎎/㎖ ). In testing the hypoglycemic activity, 20% of α-glucosidase activity was inhibited for the extracts(0.5㎎/㎖ ). GST activity was increased in the range of 1.2 to 1.6 times by adding extracts.