HDAC2 as a target for developing anti-cancer drugs

Jo, Hyein; Shim, Kyeonghee; Kim, Han-Ul; Jung, Hyun Suk; Jeoung, Dooil

doi:10.1016/j.csbj.2023.03.016

상세 보기

HDAC2 as a target for developing anti-cancer drugs

Jo, Hyein;
Shim, Kyeonghee;
Kim, Han-Ul;
Jung, Hyun Suk;
Jeoung, Dooil

Citations

WEB OF SCIENCE

58

Citations

SCOPUS

65

초록

Histone deacetylases (HDACs) deacetylate histones H3 and H4. An imbalance between histone acetylation and deacetylation can lead to various diseases. HDAC2 is present in the nucleus. It plays a critical role in modifying chromatin structures and regulates the expression of various genes by functioning as a tran-scriptional regulator. The roles of HDAC2 in tumorigenesis and anti-cancer drug resistance are discussed in this review. Several reports suggested that HDAC2 is a prognostic marker of various cancers. The roles of microRNAs (miRNAs) that directly regulate the expression of HDAC2 in tumorigenesis are also discussed in this review. This review also presents HDAC2 as a valuable target for developing anti-cancer drugs.(c) 2023 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creative-commons.org/licenses/by/4.0/).

키워드

Anti-cancer drugs; Anti-cancer drug resistance; Histone deacetylase 2; Prognostic marker; Tumorigenesis; HISTONE DEACETYLASE 2; LUNG-CANCER CELLS; NF-KAPPA-B; TUMOR-SUPPRESSOR; HEPATOCELLULAR-CARCINOMA; PROMOTES PROLIFERATION; SELECTIVE-INHIBITION; PROSTATE-CANCER; DOWN-REGULATION; UP-REGULATION

제목: HDAC2 as a target for developing anti-cancer drugs

저자: Jo, Hyein; Shim, Kyeonghee; Kim, Han-Ul; Jung, Hyun Suk; Jeoung, Dooil

DOI: 10.1016/j.csbj.2023.03.016

발행일: 2023

유형: Article

저널명: Computational and Structural Biotechnology Journal

권: 21

페이지: 2048 ~ 2057

언어: ENG

출판사: ELSEVIER

발행국가: 네덜란드

분량: 10 페이지

ISSN: E 2001-0370