더덕 물 추출물과 에탄올 추출물의 인지능 개선 활성 비교

초록

Alzheimer’s disease (AD), most common form of dementia is characterized that memory deficit and loss of cognitivefunction. This study was evaluated cognitive enhancing effect of water and ethanol extracts of Codonopsis lanceolataand compared using Morris water maze and passive avoidance test. The water and 70% ethanol extracts (100, 300 and500 mg/kg) were administered to mice. The neuroprotective effect on glutamate-induced cell death in HT22 cells was additionallyinvestigated using MTT assay. Results showed 70% ethanol extract of Codonopsis lanceolata enhanced cognitivefunction than water extract, as shown by decrease in escape latency time in Morris water maze test. In passive avoidancetest, 70% ethanol extract also increased the latency time compared to the water extract. Furthermore, 70% ethanol extractsignificantly protected neuronal cell against glutamate cytotoxicity and showed higher than neuroprotective effect of waterextract. These results indicate that 70% ethanol extract more improve spatial cognitive ability and protected neuronal cellsthan water extract.

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