고지방식이 유도 비만 랫드에 대한 유황오곡충 추출물의 지질감소 메카니즘

초록

This study was carried out to determine the action mechanism of sulfur-grain larvaeextract (SGE) on anti-obesity and the reduction of blood lipid level in high-fat diet induced obesemodel animals. Animals were classified into a normal diet group (NC, normal control), HFD(high-fat diet without SGE), HFD 15 (high-fat diet + oral administration of 15 mg of SGEextract per 100 g body weight) and HFD 30 (high-fat diet + oral administration of 30 mg ofSGE extract per 100 g body weight). The body weight gain declined in HFD 15 and HFD 30groups compared with the HFD group, even though the diet intake increased significantly. Theweight of liver and adipose tissue increased significantly in HFD group compared with in the HFD15 and HFD 30 groups. Triglyceride, total cholesterol, LDL-C and AI decreased in HFD 15 andHFD 30 groups compared with in the HFD group, but the contents of HDL-C increasedsignificantly. Expression of SREPB-1α, SREPB-2 mRNA in the liver was lower in the high-fatdiet group compared with the HFD group, but the expression of LPL mRNA in adipose tissue andPPARα increased significantly. Fat accumulation in the liver tissues and liver damage were greatlyreduced in HFD 15 and HFD 30 groups compared with in the HFD group. The size of adipocytesbecame smaller in the HFD 15 and HFD 30 groups compared with HFD group. In conclusion, thisresearch discovered for the first time that grain maggot has anti-obesity effects, by reducing theabdominal fat of obese model animals and lowering blood lipid level through the down-regulationof SREPB-1α and SREPB-2 mRNA and the up-regulation of PPAR-α mRNA.

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