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Induction method of tyrosine kinase A-mediated cell death in rat pheochromocytoma
- Ahn, JY;
- Kang, L;
- Kim, HJ;
- Kang, HJ;
- Kim, SH;
- 외 7명
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1초록
Nerve Growth Factor (NGF) is a neurotrophic factor that prevents apoptosis in neuronal progenitor cells. In rat pheochromocytoma (PC12) cells, tyrosine kinase A receptor (TrkA) mediates neurotrophic or protective effects, while p75 neurotrophin receptor (p75NTR) functions as a death receptor. We have determined whether TrkA mediates any cytotoxic effect. Following serum deprivation, TrkA expression increased 2.2-fold and apoptosis began with expression of Bax proapoptotic protein. Application of NGF halved cell viability but this was reversed by K252a, the TrkA inhibitor. These results confirmed the paradoxical cytotoxic effect of neurotrophic NGF via TrkA in PC12 cells following serum deprivation.
키워드
apoptosis; nerve growth factor; rat pheochromocytoma PC12 cell; tyrosine kinase A; NERVE GROWTH-FACTOR; PC12 CELLS; TRKA RECEPTORS; P75; APOPTOSIS; SURVIVAL
- 제목
- Induction method of tyrosine kinase A-mediated cell death in rat pheochromocytoma
- 저자
- Ahn, JY; Kang, L; Kim, HJ; Kang, HJ; Kim, SH; Kim, JY; Kim, SK; Wang, KC; Cho, BK; Lee, KW; Roh, JK; Kim, M
- 발행일
- 2005-04
- 유형
- Article
- 권
- 27
- 호
- 8
- 페이지
- 583 ~ 587