Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance

Kwon, Yoojung; Kim, Youngmi; Jung, Hyun Suk; Jeoung, Dooil

doi:10.3390/ijms20010051

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Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance

Kwon, Yoojung;
Kim, Youngmi;
Jung, Hyun Suk;
Jeoung, Dooil

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26

초록

Histone modification is associated with resistance to anti-cancer drugs. Epigenetic modifications of histones can regulate resistance to anti-cancer drugs. It has been reported that histone deacetylase 3 (HDAC3) regulates responses to anti-cancer drugs, angiogenic potential, and tumorigenic potential of cancer cells in association with cancer-associated genes (CAGE), and in particular, a cancer/testis antigen gene. In this paper, we report the roles of microRNAs that regulate the expression of HDAC3 and CAGE involved in resistance to anti-cancer drugs and associated mechanisms. In this review, roles of HDAC3-miRNAs-CAGE molecular networks in resistance to anti-cancer drugs, and the relevance of HDAC3 as a target for developing anti-cancer drugs are discussed.

키워드

anti-cancer drug-resistance; histone deacetylase-3; cancer; testis antigen CAGE; epidermal growth factor receptor; micro RNAs; molecular network; HISTONE DEACETYLASE INHIBITORS; CANCER/TESTIS ANTIGEN CAGE; CANCER STEM-CELLS; B-DEPENDENT TRANSCRIPTION; FEEDBACK LOOP; BREAST-CANCER; GASTRIC-CANCER; EXPRESSION; HDAC3; DIFFERENTIATION

제목: Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance

저자: Kwon, Yoojung; Kim, Youngmi; Jung, Hyun Suk; Jeoung, Dooil

DOI: 10.3390/ijms20010051

발행일: 2019-01-01

유형: Review

저널명: International Journal of Molecular Sciences

권: 20

호: 1

언어: ENG

출판사: MDPI

발행국가: 스위스

ISSN: E 1422-0067
P 1661-6596