A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii roots

초록

Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2), pimpinellin (3), and (3S, 4R)-3, 4-epoxypimpinellin (4). All the isolated compounds 1, 2, 3, and 4 showed moderate inhibition activities against acetylcholinesterase with the IC50 values of 10.2, 18.1, 21.5 and 22.9 μM, respectively. (3S, 4R)-3, 4-Epoxypimpinellin (4) was newly isolated from the plant source. © 2017, Korean Society of Pharmacognosy. All rights reserved.

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