The hyaluronic acid-HDAC3-miRNA network in allergic inflammation

Kim, Youngmi; Eom, Sangkyung; Park, Deokbum; Kim, Hyuna; Jeoung, Dooil

doi:10.3389/fimmu.2015.00210

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The hyaluronic acid-HDAC3-miRNA network in allergic inflammation

Kim, Youngmi;
Eom, Sangkyung;
Park, Deokbum;
Kim, Hyuna;
Jeoung, Dooil

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9

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10

초록

We previously reported the anti-allergic effect of high molecular weight form of hyaluronic acid (HMW-HA). In doing so, HA targets CD44 and inhibits FcERI signaling and cross-talk between epidermal growth factor receptor (EGFR) and FcERI. We previously reported the role of histone deacetylases (HDACs) in allergic inflammation and allergic inflammationpromoted enhanced tumorigenic potential. We reported regulatory role of HA in the expression of HDAC3. In this review, we will discuss molecular mechanisms associated with anti-allergic effect of HA in relation with HDACs. The role of microRNAs (miRNAs) in allergic inflammation has been reported. We will also discuss the role of miRNAs in allergic inflammation in relation with HA-mediated anti-allergic effects.

키워드

allergic inflammation; CD44; histone deacetylase-3; hyaluronic acid; micro RNA genes; CHEMOKINE GENE-EXPRESSION; HISTONE DEACETYLASE 3; INDUCED MURINE MODEL; MOUSE MACROPHAGES; ALVEOLAR MACROPHAGES; DEPENDENT MECHANISM; SKIN INFLAMMATION; MOLECULAR-WEIGHT; AIRWAYS DISEASE; UP-REGULATION

제목: The hyaluronic acid-HDAC3-miRNA network in allergic inflammation

저자: Kim, Youngmi; Eom, Sangkyung; Park, Deokbum; Kim, Hyuna; Jeoung, Dooil

DOI: 10.3389/fimmu.2015.00210

발행일: 2015-04-30

유형: Review

저널명: Frontiers in Immunology

권: 6