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초록
Induction of micronuclei by diesel emission particle extract (DEPE) in mouse bone marrow cells was suppressed by pre-treatment with ascorbic acid, α-tocopherol or glutathione (GSH). These compounds were given orally to mice at the dose of 1, 10 or 100 mg/kg/day for 5 consecutive days. The dose of DEPE (200 mg/kg) was administered intraperitoneally once to mice with the 5th administration of test compounds. Ascorbic acid, α-tocopherol and GSH all showed the dose-dependent suppression on DEPE-induced micronuclei. © 1989 The Pharmaceutical Society of Korea.
키워드
α-Tocopherol; Anticlastogenic effect; Ascorbic acid; Diesel emission particle extract; Glutathione; Micronucleus test
- 제목
- Suppression of diesel emission particle extract-induced micronuclei in mouse bone marrow cells by pre-treatment with ascorbic acid, α-tocopherol or glutathione
- 저자
- Heo, Moonyoung; Choi, Seong-kyu; Yu, Ki-seon; Kim, Hyun-pyo; Sohn, Donghun Huhn
- 발행일
- 1989
- 유형
- Article
- 권
- 12
- 호
- 2
- 페이지
- 94 ~ 98