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DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium
- Lozano, Manuel;
- Yousefi, Paul;
- Broberg, Karin;
- Soler-Blasco, Raquel;
- Miyashita, Chihiro;
- ... Kim, Woo Jin;
- 외 22명
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24초록
Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (beta = 2.28 x 10-4, p-value = 5.87 x 10-5) in relation to prenatal MeHg exposure. In child blood, we identified
키워드
- 제목
- DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium
- 저자
- Lozano, Manuel; Yousefi, Paul; Broberg, Karin; Soler-Blasco, Raquel; Miyashita, Chihiro; Pesce, Giancarlo; Kim, Woo Jin; Rahman, Mohammad; Bakulski, Kelly M.; Haug, Line S.; Ikeda-Araki, Atsuko; Huel, Guy; Park, Jaehyun; Relton, Caroline; Vrijheid, Martine; Rifas-Shiman, Sheryl; Oken, Emily; Dou, John F.; Kishi, Reiko; Gutzkow, Kristine B.; Annesi-Maesano, Isabella; Won, Sungho; Hivert, Marie-France; Fallin, M. Daniele; Vafeiadi, Marina; Ballester, Ferran; Bustamante, Mariona; Llop, Sabrina
- 발행일
- 2022-03
- 유형
- Article
- 권
- 204
- 언어
- ENG
- 출판사
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- 발행국가
- 미국
- ISSN
- E 1096-0953
P 0013-9351