비스테로이드소염제 관련 소화성 궤양의 최신지견

초록

Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic, antipyretic, and anti-inflammatory properties and are widelyused for treating musculoskeletal and cardiovascular diseases. Notwithstanding these therapeutic efficacies, gastrointestinaltoxicity is the major health problem associated with NSAID use. NSAID-related peptic ulcers are a well-known complication due todirect mucosal injury and cyclooxygenase inhibition. Risk factors for NSAID-related peptic ulcers include a prior history of pepticulcer; age > 65 years; high-dose NSAID therapy; and concurrent use of aspirin (including low dose), corticosteroids, oranticoagulants. In addition, Helicobacter pylori infection is an independent risk factor; therefore, eradication therapy isrecommended in high-risk patients using NSAIDs. Currently, misoprostol, H2-receptor antagonists, proton pump inhibitors, andCOX-2 selective inhibitors are used to prevent and treat NSAID-related peptic ulcers. Further, strategic approaches are requiredthrough appropriate NSAID use and risk factor stratification to prevent NSAID-related peptic ulcers and associated complications.

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