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The versatile conversion of lactams to the α-alkylated azacycles via cyclic N,O-acetal TMS ether
- Suh, YG;
- Kim, SH;
- Jung, JK;
- Shin, DY
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34초록
The efficient preparation of the cyclic N,O-acetals from lactams by DIBAL reduction followed by direct trapping of the resulting N,O-hemiacetals using TMSOTf/pyridine system is described. In addition, the facile nucleophilic addition of various carbon nucleophiles at the carbonyl carbons of the lactams through the corresponding N,O-acetals is also reported. (C) 2002 Published by Elsevier Science Ltd.
키워드
CARBOXYLIC-ACID ESTERS; DIBALH REDUCTION; GENERAL-SYNTHESIS; AMINO ESTERS; ACETALS; INTERMEDIATE; ACETYLATION
- 제목
- The versatile conversion of lactams to the α-alkylated azacycles via cyclic N,O-acetal TMS ether
- 저자
- Suh, YG; Kim, SH; Jung, JK; Shin, DY
- 발행일
- 2002-04-22
- 유형
- Article
- 권
- 43
- 호
- 17
- 페이지
- 3165 ~ 3167