Magnetic Nanovector Enabling miRNA-34a Delivery for CD44 Suppression with Concurrent MR Imaging

Lee, Hwunjae; Kim, Hyun-Ouk; Son, Hye-Young; Lee, Sang-Bock; Jang, Eunji; Kang, Byunghoon; Haam, Seungjoo; Lim, Eun-Kyung; Huh, Yong-Min

doi:10.1166/jnn.2016.13797

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Magnetic Nanovector Enabling miRNA-34a Delivery for CD44 Suppression with Concurrent MR Imaging

Lee, Hwunjae;
Kim, Hyun-Ouk;
Son, Hye-Young;
Lee, Sang-Bock;
Jang, Eunji;
외 4명

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15

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SCOPUS

13

초록

We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.

키워드

miRNA; CD44; Gene Delivery; Magnetic Nanovector; Surface Modification; Magnetic Resonance Imaging; CANCER STEM-CELLS; SYSTEMIC DELIVERY; IN-VITRO; MICRORNA; NANOPARTICLES; INVASION; GENE; FUNCTIONALIZATION; MIGRATION; MIR-34A

제목: Magnetic Nanovector Enabling miRNA-34a Delivery for CD44 Suppression with Concurrent MR Imaging

저자: Lee, Hwunjae; Kim, Hyun-Ouk; Son, Hye-Young; Lee, Sang-Bock; Jang, Eunji; Kang, Byunghoon; Haam, Seungjoo; Lim, Eun-Kyung; Huh, Yong-Min

DOI: 10.1166/jnn.2016.13797

발행일: 2016-12

유형: Article

저널명: Journal of Nanoscience and Nanotechnology

권: 16

호: 12

페이지: 12939 ~ 12946

언어: ENG

출판사: AMER SCIENTIFIC PUBLISHERS

발행국가: 미국

분량: 8 페이지

ISSN: E 1533-4899
P 1533-4880