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초록
3,6-Disubstituted pyridazine analogs (2a and 2b) were synthesized from commercially available 3,6-dichloropyridazine in two steps. The synthesized compounds were evaluated for their GPR119 agonistic activity. Bothcompounds exhibited much stronger EC50 values than that of oleylethanolamide (OEA) and were proved to be partialagonists. These results indicate that the pyridazine ring can be used as a potential heterocycle scaffold for GPR119agonists.
키워드
GPR119 agonists; Antidiabetic agents; Fragment structure; Bioequivalent; Pyridazine analogs; Lead compounds
- 제목
- 피리다진계 항당뇨 화합물의 합성 및 평가
- 제목 (타언어)
- Synthesis and Evaluation of Pyridazine Analogs as Potential Antidiabetic Agents
- 저자
- 보뒤비엣; 박해일
- 발행일
- 2021-08
- 유형
- Y
- 저널명
- 약 학 회 지
- 권
- 65
- 호
- 4
- 페이지
- 331 ~ 334