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The Isolation of Acetylcholinesterase Inhibitory Constituents from Lycoris radiata using On-line HPLC-biochemical Detection System
- 양희정;
- 윤기동;
- 진영원;
- Young Choong Kim;
- Jinwoong Kim
초록
Bioactivity-guided fractionation using on-line HPLC biochemical detection system on CHCl3-soluble fraction of Lycoris radiata led to the isolation of deoxylycorenine (1), O-demethylhomolycorine (2), galanthamine (3), lycoramine (4), mixture of 6a-and 6b-haemanthidine (5), and lycorine (6), identified by spectroscopic data and physicochemical property. Among the isolated compounds, 1, 3 and 6 showed acetylcholinesterase inhibitiory activities with IC50 values of 18.0, 12.0 and 16.6 mM, respectively, in in vitro colorimetric microplate assay. Keywords - Lycoris radiata, Amaryllidaceae, acetylcholinesterase, galanthamine, deoxylycorenine, lycorine, flow biochemical detection system, on-line HPLC-biochemical detection system
키워드
Lycoris radiata; Amaryllidaceae; acetylcholinesterase; galanthamine; deoxylycorenine; lycorine; flow biochemical detection system; on-line HPLC-biochemical detection system
- 제목
- The Isolation of Acetylcholinesterase Inhibitory Constituents from Lycoris radiata using On-line HPLC-biochemical Detection System
- 저자
- 양희정; 윤기동; 진영원; Young Choong Kim; Jinwoong Kim
- 발행일
- 2010-12
- 유형
- Y
- 권
- 16
- 호
- 4
- 페이지
- 228 ~ 232
- 언어
- ENG
- 출판사
- 한국생약학회
- 발행국가
- 대한민국
- 분량
- 5 페이지
- ISSN
- P 1226-3907