나노 입자화 한 복분자 저온 추출물의 면역 활성 증진

초록

This study was performed to improve immune activities of Rubus coreanus Miquel by encapsulation of nanoparticles. Immuno-activities of R. coreanus were investigated through aqueous extracts associated with process of water at 60℃. It showed high promotion of human B and T cells growth about 50%, compared to the case of other conditions. The secretion of IL-6 and TNF-α was also enhanced as 2.44 × 10−4 pg/cell and 1.94 × 10−4 pg/cell, results by adding nano samples. NK cell activation was improved up to 29% higher than the conventional extraction process. The secretion of NO from macrophage showed 14.9 μM on the nano-encapsulation process extracts, which was higher than others. The size of nanoparticles was in the range of 50~300㎚, which can effect the penetration into the cells. It was clearly observed by real time confocal microscope.

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