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초록
Surfactin is a natural biosurfactant derived from Bacillus subtilis and has various biological activities such as anticancer, antiplatelet, and anti-inflammatory effects. In this study, the inhibitory mechanism of surfactin in NO production from macrophages; was examined. Surfactin downregulated LPS-induced NO production in RAW264.7 cells and primary macrophages; with IC50 values of 31.6 and 22.4 mu M, respectively. Immunoblotting analysis showed that surfactin strongly blocked the phosphorylation of IKK and I kappa B alpha and the nuclear translocation of NF-kappa B (p65). Therefore, these data suggest that surfactin may act as a bacterium-derived anti-inflammatory agent with anti-NF-kappa B activity.
키워드
Surfactin; Bacillus subtilis; nitric oxide; anti-inflammatory effect; lipopolysaccharide; NF-kappa B; NITRIC-OXIDE PRODUCTION; MURINE RAW-264.7 CELLS; SESQUITERPENE LACTONE; INDUCED TRANSCRIPTION; SIGNAL-TRANSDUCTION; CYNAROPICRIN; SUPPRESSION; CYTOKINES; 3-KINASE
- 제목
- Surfactin Blocks NO Production in Lipopolysaccharide-activated Macrophages by Inhibiting NF-κB Activation
- 저자
- Byeon, Se Eun; Lee, Yong Gyu; Kim, Byung Hun; Shen, Ting; Lee, Sang Yeol; Park, Hwa Jin; Park, Seung-Chun; Rhee, Man Hee; Cho, Jae Youl
- 발행일
- 2008-12
- 유형
- Article
- 권
- 18
- 호
- 12
- 페이지
- 1984 ~ 1989