Recent Advances in the Total Synthesis of Sulfur-containing Natural Products

초록

Sulfur imparts distinctive reactivity, conformational bias, and redox versatility to natural products, giving rise to potent antibacterial, antiviral, anticancer, and enzyme-inhibitory activities. Over the past five years, highly regio- and stereoselective C-S bond-forming strategies have enabled concise access to increasingly complex sulfur frameworks. This review surveys representative total syntheses reported from March 2020 to January 2024, grouped by sulfur functionality-thioethers, disulfides, sulfoxides, thioacetals, thiazoles, thiazolines, and isothiazolinones-and shows how these advances shorten step counts, facilitate late-stage diversification, and provide a foundation for rapid structure-activity relationship studies of sulfur-rich scaffolds poised for therapeutic development.

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