Enantioselective inclusion between terbutaline enantiomers and hydroxypropyl-β-cyclodextrin

초록

Solid inclusion complexes between terbutaline (racemate, S-(+)-enantiomer, and R-(-)-enantiomer, respectively) and hydroxypropyl-β-cyclodextrin (HP-β-CD) were prepared by the lyophilization method. Characterization of each complex was achieved with differential scanning calorimetry (DSC). Stoichiometry between terbutaline and HP-β-CD was studied by UV spectroscopy, and stability constants between terbutaline (racemic, S-(+)-enantiomer and R-(-)-enantiomer) and HP-β-CD was also determined by UV absorption and chromatographic retention method. Structural study to confirm exact location of chiral discrimination between terbutaline enantiomers and HP-β-CD was performed by 1H NMR spectroscopy. From this experiment, enantioselective binding of terbutaline enantiomers to HP-β-CD was clearly demonstrated. Copyright (C) 1998 Elsevier Science B.V.

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