구멍갈파래의 면역활성 증진을 위한 추출방법 비교

초록

The purpose of this study was to investigate the immunomodulatory effect of Ulva pertusa kjellman extract after undergoing a low temperature and high-pressure extraction process. First, the extracts obtained under the extraction conditions of 150 MPa and 80oC showed a relatively high antioxidant activity, with 90% super oxide radical activity compared to the extracts from conventional extraction process with water at 100oC. This extract also improved the growth of both human immune B and T cells up to 14.5×104 cells/mL and 14.2×104 cells/mL compared to 9.1×104 cells/mL in adding the extracts from conventional processes. It was found that the extracts obtained at 100 MPa and 60oC showed better activities in NK cell growth and NO production from macrophage as 11.8×102 cells/mL and 30.0 μM. Overall, the extracts from high pressure and low temperature extraction process had relatively higher immune activation activity, possibly because the low temperature and high pressure extraction process may have higher yields of active compounds and have less damage to useful ingredients from relatively weak marine natural resources, such as Ulva pertusa kjellmann than that from the conventional extraction system.

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