운동을 통한 근육 손상과 Cytokine 반응

초록

The aim of present study was to investigate the variation of selected serum muscle damage markers, and cytokine(TNF-α, IL-6) response to eccentric exercise. The running tests were performed on a treadmill for 30 min and all subjects(n=10) of present study participated in two different kinds of experimental conditions.: one was level running(LR) and the others was downhill running(DR) at a decline angle -14 % with their favorable running speed. The mean serum CK activity of DR was higher than that of LR group at the 12 h, 24 h, and 48 h after finishing 30min running test, and there were significant difference between LR and DR conditions following the running exercise(p<.05). The mean serum LDH activity of LR was higher than that of DR group at the 12 h after finishing 30min running test, and there were significant difference between LR and DR conditions following the running exercise(p<.05). There was no significant different in the mean plasma TNF-α between LR and DR conditions(p>.05). There was significant different in the mean plasma IL-6 concentration between LR and DR conditions(p<.05). In summary, an indirectly marker of muscle damage, serum CK activity was one of most important factor. Eccentric exercise-induced increased in serum interleukin-6(IL-6) in human is related to muscle damage.