상세 보기
Identification of a new tadalafil analogue in an adulterated dietary supplement: Trans-Bisprehomotadalafil
- Lee, Ji Hyun;
- Kim, Hyung Joo;
- Mandava, Suresh;
- Hwang, Jungjoong;
- Park, Hyoung Joon;
- ... Lee, Jongkook;
- 외 2명
WEB OF SCIENCE
15SCOPUS
15초록
A new tadalafil analogue was identified along with homotadalafil during routine screening of an adulterated dietary supplement using HPLC-DAD. The UV spectrum of this analogue was almost identical with that of tadalafil. This compound was isolated from the supplement by using semi-preparative HPLC and its structure was subsequently elucidated by performing Q-TOF/MS/MS and NMR spectroscopic experiments. The spectral data indicate that this tadalafil analogue is a dimeric compound that consists of an ethylamino group and two pretadalafil moieties. NOE experiments and comparison with H-1 NMR spectra of tadalafil and trans-tadalafil suggested the trans-relationship between the substituents on piperidine rings in the pretadalafil moieties. (C) 2015 Elsevier B.V. All rights reserved.
키워드
- 제목
- Identification of a new tadalafil analogue in an adulterated dietary supplement: Trans-Bisprehomotadalafil
- 저자
- Lee, Ji Hyun; Kim, Hyung Joo; Mandava, Suresh; Hwang, Jungjoong; Park, Hyoung Joon; Cho, Sooyeul; Baek, Sun Young; Lee, Jongkook
- 발행일
- 2015-11-10
- 유형
- Article
- 권
- 115
- 페이지
- 352 ~ 358