Photo-responsive liposomes decorated with hydrophobically modified poly(vinyl alcohol)-coumarin conjugate

초록

Photo-responsive liposome was developed by modifying the surface of egg yolk phosphatidylcholine (egg PC) liposomes with hydrophobically modified poly(vinyl alcohol)-epoxypropoxy coumarin conjugate (HmPVA-EPC). Decanoyl chloride (DC) was used as a hydrophobic pendant for the hydrophobic modification of PVA. The fluorescence quenching of liposomes was more than 65% when the ratio of lipid/HmPVA-EPC was 1:0.01-1:0.1, but the value was less than 35% in the ratio range of 1:0.2-1:1. Under UV irradiation (lambda = 254 nm), egg PC liposomes of which lipid/HmPVA-EPC ratio was 1:0.1 readily release their content for 60 min possibly due to the photo-dimerization of EPC residues. (C) 2012 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

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