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초록
Structural alterations of wogonin were conducted to observe the role of each functional group at the A-ring of wogonin on the inhibitory activities against COX-2 catalyzed PGE(2) production from LPS-induced RAW 264.7 cells. Serial deletion of the functional groups at the A-ring of wogonin exhibited low to comparable bioactivity. The present study validated that all the functional groups at the A-ring of wogonin are important factors to exhibit the optimum inhibitory activities.
키워드
Structural alterations; Wogonin; PGE(2) production; COX-2; Anti-inflammatory activity; NITRIC-OXIDE PRODUCTION; SCUTELLARIA-RADIX; FLAVONOID WOGONIN; PLANT FLAVONE; LIPOPOLYSACCHARIDE; BAICALEIN; CYCLOOXYGENASE-2; MACROPHAGES; DERIVATIVES; SYNTHASE
- 제목
- Structural Alterations of Wogonin Significantly Reduce the Inhibitory Activity against COX-2 Catalyzed PGE2 Production from LPS-Induced RAW 264.7 Cells
- 저자
- Gurung, Santosh Kumar; Lim, Hyun; Kim, Hyun Pyo; Park, Haeil
- 발행일
- 2009-10-31
- 유형
- Article
- 권
- 17
- 호
- 4
- 페이지
- 418 ~ 421