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초록
The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic beta-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic beta-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.
키워드
Agrocybe chaxingu; blood glucose; nitric oxide (NO); polysaccharide; NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; OXYGEN-FREE RADICALS; BETA-CELL DAMAGE; RAW 264.7 CELLS; GANODERMA-LUCIDUM; RINM5F CELLS; ANTIOXIDANT ENZYMES; OXIDATIVE STRESS; INHIBITION
- 제목
- Amelioration of streptozotocin-induced diabetes by Agrocybe chaxingu polysaccharide
- 저자
- Lee, Byung Ryong; Lee, Yeom Pyo; Kim, Dae Won; Song, Ha Yong; Yoo, Ki-Yeon; Won, Moo Ho; Kang, Tae-Cheon; Lee, Kwang Jae; Kim, Kyung Hee; Joo, Jin Ho; Ham, Hun Ju; Hur, Jang Hyun; Cho, Sung-Woo; Han, Kyu Hyung; Lee, Kil Soo; Park, Jinseu; Eum, Won Sik; Choi, Soo Young
- 발행일
- 2010-04
- 유형
- Article
- 권
- 29
- 호
- 4
- 페이지
- 349 ~ 354