Inhibition of prostaglandin E2 production by synthetic Wogonin analogs

Gurung, Santosh K.; Kim, Hyun Pyo; Park, Haeil

doi:10.1007/s12272-009-2101-5

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Inhibition of prostaglandin E2 production by synthetic Wogonin analogs

Gurung, Santosh K.;
Kim, Hyun Pyo;
Park, Haeil

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WEB OF SCIENCE

16

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SCOPUS

16

초록

Effects of wogonin analogs on cyclooxygenase-2 (COX-2) catalyzed prostaglandin E-2 production on lipopolysaccharide (LPS)-induced RAW 264.7 cells were investigated. Wogonin analogs were prepared via several different synthetic pathways. Among wogonin analogs tested, 8-halogeno and 8-nitro analogs showed strong inhibitory activities against COX-2 catalyzed PGE(2) production from LPS-induced RAW 264.7 cells. Effect of wogonin was largely dependent on structural alteration of the 8-methoxy group.

키워드

Wogonin analogs; Cyclooxygenase-2 (COX-2); Prostaglandin E-2 production; PLANT FLAVONOIDS; CELLS

제목: Inhibition of prostaglandin E2 production by synthetic Wogonin analogs

저자: Gurung, Santosh K.; Kim, Hyun Pyo; Park, Haeil

DOI: 10.1007/s12272-009-2101-5

발행일: 2009-11

유형: Article

저널명: Archives of Pharmacal Research

권: 32

호: 11

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