Nanoparticle-Mediated Delivery of Flavonoids for Cancer Therapy: Prevention and Treatment

초록

Flavonoids are being explored as antioxidant molecules for the prevention of various types of cancers, such as gastric, breast, colon, pancreas, skin, liver, lung, prostate, etc. Various flavonoids have been explored for their anticancer potentials due to their ability to modulate signaling pathways responsible for the growth and proliferation of cancer cells. In addition, flavonoids also regulate the initiation of apoptosis, angiogenesis, metastasis, and invasion. However, flavonoids lack stability in the physiological fluids and are hydrophobic in nature, limiting their bioavailability and biological activity. Therefore, studies have been performed to increase their stability and bioavailability via nanoparticle-based approaches, so as to increase their biological efficacy at low doses. In this chapter, we discuss about the cancer-related signaling pathways modulated by flavonoids and their nanoparticle-mediated delivery. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

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