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Higher-Order Cycloaddition of N-Aromatic Zwitterions and Ketenes to Access Diazepine Derivatives
- Lee, Ju Young;
- Kim, Jiyoung;
- Lee, Ji Hye;
- Hwang, Hyonseok;
- Yoo, Eun Jeong
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11초록
A series of N-aromatic zwitterions that could undergo higher-order dipolar cycloadditions were prepared by a rhodium(II)-catalyzed reaction between heteroaromatic compounds and 1-sulfonyl-1,2,3-triazoles. NICS(0) and structural calculations revealed a strong correlation between the aromaticity and stability of N-aromatic zwitterions. The initial success of [5+2] cycloadditions of N-aromatic zwitterions and ketene is expected to advance their application in medicinal chemistry.
키워드
heterocycles; zwitterions; ketenes; cycloaddition; diazepines; AZOMETHINE YLIDES; REACTIVITY
- 제목
- Higher-Order Cycloaddition of N-Aromatic Zwitterions and Ketenes to Access Diazepine Derivatives
- 저자
- Lee, Ju Young; Kim, Jiyoung; Lee, Ji Hye; Hwang, Hyonseok; Yoo, Eun Jeong
- 발행일
- 2019-09
- 유형
- Article
- 권
- 8
- 호
- 9
- 페이지
- 1654 ~ 1658