Biogenic silver embedded magnesium oxide nanoparticles induce the cytotoxicity in human prostate cancer cells

초록

This work reports the synthesis, characterization, and cytotoxicity of biogenic magnesium oxide nanoparticles (MgONPs) and nanosilver embedded magnesium oxide nanoparticles (Ag-MgONPs). The formation of nanoparticles (NPs) was confirmed by the indications of color changes and precipitations. Field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) pattern studies showed the agglomeration colloids, porous, spherical, needle-shaped and crystal nature of MgONPs, whereas, the Ag-MgONPs was hexagonal, and spherical structured nanocrystals. Energy-dispersive X-ray fluorescence spectrometry (EDS) study indicated the existence of Ag, Mg, and O in NPs complex. The particle size analysis (PSA) revealed the mean size of 15.09 nm for Ag-MgONPs and 13.68 nm for MgONPs. Fourier transform infrared spectroscopy (FTIR) showed the peaks corresponding to amide, carboxylic acids, aromatics, alkene and esters from mycelial cell-free extract (MCFE). The absorbed and lattices oxygen of MgO was probably assigned in the formation of Ag-MgONPs as indicated by X-ray photoelectron spectroscopy (XPS). Cytotoxicity assay showed the Ag-MgONPs was stronger in inducing the prostate cancer (PC-3) cell death than the MgONPs. This work concluded that Ag-MgONPs could be potential therapeutics for cancer therapy. (C) 2019 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.

키워드