The Most Important Factors for Retinopathy of Prematurity in Preterm Infants

초록

Purpose : There are many known risk factors for a retinopathy of prematurity (ROP). We analyzed the most important risk factors and predictors of ROP among them. Methods : We retrospectively reviewed the medical records of all premature infants admitted to the neonatal intensive care unit (NICU) at Gangnam CHA Medical Center, Seoul between January 2010 and December 2012. All infants (n=185) were hospitalized for more than 28 days, received eye examination for ROP and showed one of the following criteria: birth weight (BW) below 1,500 g, gestational age (GA) below 32 weeks, or oxygen treatment (≥40% oxygen for more than 3 days). We divided the infants into the Non-ROP group (n=162) and the ROP group (n=23, more than stage 1) and analyzed group comparisons, risk factors and the importance of each factor of ROP by SPSS 13.0. Results : Risk factors were oxygen treatment duration [Odds ratio (OR): 1.064, 95% confidence interval (CI): 1.007-1.125, P=0.028] and intravenous (IV) steroid (OR: 1.234, 95% CI: 1.000-1.523, P=0.049) by multi-factor adjustment. The most important factor was oxygenation duration. The following factors were time to full enteral feedings, and IV steroid duration. Conclusion : The incidence of ROP will be decreased if we can reduce the length of oxygen treatment, IV steroid use and advance the full feeding achievement.

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