Sprague Dawley Rats을 이용한 현사시나무 추출물의 항산화 효능 평가

초록

This study aimed to investigate the antioxidant potential and free radical generation ability of Populus tomentiglandulosa (PT) extract in Sprague-Dawley (SD) rats. Male SD rats were fed a diet supplemented with 0.5% PT extract, as recommended by American Institute of Nutrition (AIN) for 4 weeks. Free radical generation and antioxidant potentials in the blood were measured at 2-week intervals. After 4 weeks, weight gain in the PT extract-fed group was significantly higher than that in the negative control group. However, food intake, food efficiency ratio, and weight index were not significantly different between the groups. The blood antioxidative potentials in the PT extract-fed group were higher than those in the negative control group. Free radical generation in the blood in the ascorbic acid-fed group was higher than that in the negative control group. These results suggest that supplementation with Populus tomentiglandulosa extract had beneficial effects on antioxidant potential.

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