Rip immunoreactivity significantly decreases in the stratum oriens of hippocampal CA1 region after transient forebrain ischemia in gerbils

초록

In the present study, we observed ischemia-related changes in Rip recognizing the promyelinating and myelinating oligodendrocytes in the hippocampus proper after 5 min of transient forebrain ischemia in gerbils. Rip immunore activity was significantly altered in the hippocampal CA1 region but not in the CA2/3 region after ischemic insult. in the shamoperated group, Rip immunoreactivity was shown in the cell bodies and processes of oligodendrocytes in all layers of the hippocampus proper. From IS min to 2 days after ischemic insult, Rip immunoreactivity was similar to that of sham-operated group. Three days after ischemic insult, Rip-immunore active processes were tangled in the stratum oriens of the CA1 region, and Rip protein level decreased from this time after ischernia. Thereafter, Rip immunore activity was decreased time dependently in the CA1 region. Seven days after ischemic insult, Rip-immunore active processes were tangled and densely detected in the stratum oriens adjacent to the stratum pyramidale. In brief, these results indicate that the significant decrease of Rip immunoreactivity in processes in the stratum oriens of the hippocampal CA1 region occurs at late time after ischernia, and this decrease in Rip immunoreactivity may be associated with delayed neuronal death of CA1 pyramidal cells. (c) 2005 Elsevier B.V. All rights reserved.

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