Near-infrared and Thermo-sensitive Liposomes Incorporating Thiolated-carboxymethyl Cellulose-capped Gold Nanoparticles and Poly(N-isopropylacrylamide)

초록

Near-infrared (NIR) irradiation-responsive drug carriers are of great interest because the light is tissue-penetrating and the carriers administered into human body can be made to release their payloads at a specific site in an active manner using the external stimulus (i.e., NIR irradiation). In this study, thermo-responsive liposomes bearing gold nanoparticle (GNP) were developed as a NIR irradiation-responsive drug carrier. Dipalmitoylphosphatidyl-choline (DPPC) liposome was surface-decorated with hydrophobically modified thiolated carboxymethyl cellulose (Hm TL-CMC)-capped GNP and hydrophobically modified poly(N-isopropylacrylamide) (Hm PNIPAM). GNP was prepared using Hm TL-CMC as a reducing agent for gold ions and a capping material for GNP. DPPC liposomes incorporating Hm TL-CMC-capped GNP and Hm PNIPAM were prepared by a film hydration and sonication method and they exhibited a multi lamellar structure along with GNP on its transmission electron micrograph. The temperature-responsive release of DPPC liposome was promoted when the liposome was incorporating Hm PNIPAM, possibly due to the thermal contraction of the polymer chains. DPPC liposome incorporating Hm TL-CMC-capped GNP showed a NIR-responsive release, possibly due to the photothermal effect of GNP, and the NIR-responsive release was enhanced when the liposome was bearing Hm PNIPAM.

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