Inhibitory activities of Chinese herbs that clear heat on 3α- hydroxysteroid dehydrogenase

초록

3α-Hydroxysteroid dehydrogenase (3α-HSD) is one of the main enzymes involved in the metabolism of the active androgen, dihydrotestosterone. The NAD(P)-linked 3α-HSD of rat liver cytosol is powerfully inhibited by the non-steroidal anti-inflammatory drugs in rank-order of their therapeutic potency. This observation has now been developed into a rapid screen for predicting the potency of products that show anti-inflammatory effect. 52- Chinese Herbs that clear heat were screened by using this method.

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