Constituents of the Stem of Angelica gigas with Rat Lens Aldose Reductase Inhibitory Activity

초록

Eleven compounds were isolated from the stem of Angelica gigas. On the basis of spectral data, these compounds were identified as isoimperatorin (1), 7-methoxy-5-prenyloxycoumarin (2), imperatorin (3), decursin (4), bergapten (5), psoralen (6), xanthotoxin (7), p-hydroxyphenethyl trans-ferulate (8), visamminol (9), scopoletin (10), and 3'-hydroxyxanthyletin (11). All isolates were evaluated in vitro for their inhibitory activities on the rat lens aldose reducatase. Tested compounds (1-11) exhibited inhibitory activities against rat lens aldose reductase with IC50 values ranging from 2.59 to 191.91 mu M.

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