상세 보기
Constituents of the Stem of Angelica gigas with Rat Lens Aldose Reductase Inhibitory Activity
- Park, Hyun Young;
- Kwon, Soon Bae;
- Heo, Nam Kee;
- Chun, Wan Joo;
- Kim, Myong Jo;
- ... Kwon, Yong Soo
Citations
WEB OF SCIENCE
20Citations
SCOPUS
25초록
Eleven compounds were isolated from the stem of Angelica gigas. On the basis of spectral data, these compounds were identified as isoimperatorin (1), 7-methoxy-5-prenyloxycoumarin (2), imperatorin (3), decursin (4), bergapten (5), psoralen (6), xanthotoxin (7), p-hydroxyphenethyl trans-ferulate (8), visamminol (9), scopoletin (10), and 3'-hydroxyxanthyletin (11). All isolates were evaluated in vitro for their inhibitory activities on the rat lens aldose reducatase. Tested compounds (1-11) exhibited inhibitory activities against rat lens aldose reductase with IC50 values ranging from 2.59 to 191.91 mu M.
키워드
Angelica gigas; C-13-nuclear magnetic resonance; chromone; coumarins; diabetic complications; 3'-hydroxyxantyltein; inhibitory activity; rat lens aldose reductase; stem; DIABETIC COMPLICATIONS; FURANOCOUMARINS; COUMARINS; DAHURICA; ROOT; ACETYLCHOLINESTERASE; AGGREGATION; ACTIVATION; COMPOUND; CELLS
- 제목
- Constituents of the Stem of Angelica gigas with Rat Lens Aldose Reductase Inhibitory Activity
- 저자
- Park, Hyun Young; Kwon, Soon Bae; Heo, Nam Kee; Chun, Wan Joo; Kim, Myong Jo; Kwon, Yong Soo
- 발행일
- 2011-04
- 유형
- Article
- 권
- 54
- 호
- 2
- 페이지
- 194 ~ 199