The Effect of Long-term Exercise on GLUT-4 Translocation in Human Skeletal Muscle

초록

The purpose of this study in to investigate plasma membrane and/or intracellular Vamp2, Syntaxin4, GLUT-4 protein and total muscle glycogen concentration in skeletal muscle following long-tern exercise. Subjects who were underwent ACLR were divided into two groups (training group, n=5 and control group, n=5). Syntaxin4 protein expression is markedly increased in TRAINING compared to CON. GLUT-4 and Vamp2 in plasma membrane were significantly overexpressed in TRAINING (p<.05; .001); But, GLUT-4 and Vamp2 protein in an intracellular portion were significantly lower in TRAINING compared to CON (p<.05; .001). Total glycogen concentration was significantly higher in TRAINING compared to CON (p<.001). In these results, Increased glycogen content of skeletal muscle with exercise training adaptation is likely due to interactions of higher membrane GLUT-4 protein expression with v-t SNARE complex.

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