Anti-inflammatory constituents of polygonum bistorta

초록

Five compounds were isolated from the BuOH fraction of Polygonum bistorta (Polygonaceae). On the basis of spectral data, these compounds were established as caffeic acid, quecimeritrin, avicularin, gallic acid and protocatechuic acid. The inhibitory activities on 3 α-hydroxysteroid dehydrogenase (3 α-HSD) of isolated compounds were compared. IC₅₀ value of isolated compounds were 133.57 μg/ml (caffeic acid), 89.1 μg/ml (quercimeritrin), 189.85 μg/ml (avicularin), 140.69 μg/ml (gallic acid) and 165.27 μg/ml (protocatechuic acid) respectively. Although all compounds showed lower inhibition activities than BuOH fraction (IC₅₀<50 μg/ml) of Polygonum bistorta, it showed higher inhibition activities than aspirin (IC₅₀ 246.81 μg/ml).

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