실험적으로 유발된 급성 췌장염 견에서 컬러도플러 츠음파를 이용한 전방 십이지장 동맥 혈류의 혈역학적 변화에 대한 평가

초록

For the study of the hemodynamic changes of the cranial pancreaticoduodenal arterial flow(cPDAF) in the dog with acute pancreatitis, acute pancreatitis was experimentally induced in 10 dogs by the injection of oleic acid into the accessory pancreatic duct. The parameters of cPDAF were measured by transcutaneous pulsed-wave Doppler ultrasonography. The hemodynamic changes included resistive index(RI), pulsatility index(PI) and maximum velocity (Vmax). Ultrasonographic scans were performed before the induction of pancreatitis and once daily for five days after the induction. The RI, PI and Vmax were increased with day as follows; the RI prior to induction was 0.625±0.096 (mean±SD), the PI was 1.117±0.289 and the Vmax was 0.349±0.094m/s. After five days, the RI was 0.727±0.051 (p＜0.01), the PI was 1.480±0.284(p＜0.01) and the Vmax was 0.585±0.114m/s(p＜0.001). These results show that there is some relation between the increase of the RI, PI and Vmax of cPDAF and the progress of acute pancreatitis in dogs. Therefore, the measurements of the hemodynamic changes of cPDAF may be a valuable technique for the evaluation of acute pancreatitis in dogs.

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