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초록
8-Acyl and 8-sulfonylamidowogonin analogues were synthesized as potential anti-inflammatory agents. Nitration of 5,7-dihydroxyflavone (chrysin) followed by methylation of phenol groups and reduction of nitro group yielded 8-aminowogonin analogues. Acylation and sufonylation of 8-aminowogonin followed by demethylation reactions gave the title compunds. The synthesized wogonin analogues showed much reduced inhibitory activity on prostaglandin E₂ (PGE₂) production.
키워드
wogonin; 8-acylamido; 8-arylsulfonamido; prostaglandin E₂ (PGE₂) production
- 제목
- 8-아미노우고닌 유도체의 Prostaglandin E₂ 생성에 대한 저해작용
- 제목 (타언어)
- Inhibitory Activity of 8-Aminowogonin Analogues Against Prostaglandin E₂ Production
- 저자
- 장진희; 신관석; 김현표; 박해일
- 발행일
- 2008-02
- 유형
- Y
- 저널명
- 약 학 회 지
- 권
- 52
- 호
- 1
- 페이지
- 85 ~ 91