Effects of isoflavonoids on mouse lymphocyte proliferation in vitro

초록

The suppressive activity of isoflavonoids against lymphocyte proliferation in vitro was examined. Isoflavonoid derivatives tested were isoflavones isolated from Pueraria radix and synthesized 7-O-substituted biochanin A derivatives. The certain isoflavones such as biochanin A and 2-carbethoxybiochanin A were found to possess the suppressive activity against concanavaline A (Con A)-induced lymphocyte proliferation from mouse spleen. Against mixed lymphocyte culture reaction, biochanin A, 2-carbethoxybiochanin A, daidzein, formononetin, genistein and 7-O-isopropylbiochanin A showed the suppressive activity at 10−5 M. However, all isoflavones tested did not show the suppressive activity against lymphocyte proliferation induced by B-cell mitogen, lipopolysaccharide (LPS). In general, isoflavones were revealed to be less active than flavones/flavonols. © 1994, The Pharmaceutical Society of Korea. All rights reserved.

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