Metal-free, Bronsted acid-mediated synthesis of coumarin derivatives from phenols and propiolic acids

Choi, Hyuck; Kim, Jaehyun; Lee, Kooyeon

doi:10.1016/j.tetlet.2016.06.039

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Metal-free, Bronsted acid-mediated synthesis of coumarin derivatives from phenols and propiolic acids

Choi, Hyuck;
Kim, Jaehyun;
Lee, Kooyeon

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WEB OF SCIENCE

27

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SCOPUS

29

초록

A novel synthesis of coumarin derivatives by Bronsted acid-mediated condensation and intramolecular cyclization of phenols and propiolic acids was reported. This transformation requires the use of TfOH in place of a conventional metal mediator, and it occurs under mild conditions and provides rapid access to coumarin derivatives in good yields. (C) 2016 Published by Elsevier Ltd.

키워드

Coumarin; Bronsted acid; Trifluoromethanesulfonic acid; Condensation; Cyclization; N-SULFONYL AZIDES; C-H BONDS; HYDROAMINATIONS; COMPLEXES; CYCLIZATION; MILD

제목: Metal-free, Bronsted acid-mediated synthesis of coumarin derivatives from phenols and propiolic acids

저자: Choi, Hyuck; Kim, Jaehyun; Lee, Kooyeon

DOI: 10.1016/j.tetlet.2016.06.039

발행일: 2016-08-10

유형: Article

저널명: Tetrahedron Letters

권: 57

호: 32

페이지: 3600 ~ 3603